Clone:
REA1094
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
4Ig-B7-H3, B7-H3, B7RP-2

Specifications for CD276 Antibody, anti-human, REAfinity™

Overview

Clone REA1094 recognizes the human CD276 antigen, a type I transmembrane protein expressed at low levels in human liver, lung, bladder, testis, prostate, breast, placenta, lymphoid organs, and many human cancers. Surface expression can be induced on T cells, natural killer cells, and macrophages as well as on dendritic cells (DC) by interferon γ (IFN-γ) and on monocytes by granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4). CD276 has been shown to function as costimulatory molecule for T cell activation by inducing T cell proliferation and IFN-γ production.
Additional information: Clone REA1094 displays negligible binding to Fc receptors.

Alternative names

4Ig-B7-H3, B7-H3, B7RP-2

Detailed product information

Technical specifications

CloneREA1094
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD276
Alternative names of antigen4Ig-B7-H3, B7-H3, B7RP-2
Molecular mass of antigen [kDa]54
Distribution of antigenB cells, dendritic cells, epithelial cells, macrophages, monocytes, NK cells, T cells, bladder, liver, lung, testicle, prostate, breast, placenta, tumor
Entrez Gene ID80381
RRIDAB_2733633, AB_2733796, AB_2733797, AB_2733364, AB_2733365, AB_2732972, AB_2732973, AB_2733221, AB_2733222, AB_2733108, AB_2733109, AB_2733027, AB_2733028, AB_2733514, AB_2733515, AB_2733632

Resources for CD276 Antibody, anti-human, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD276 Antibody, anti-human, REAfinity™

Publications

  1. Chapoval, A. I. et al. (2001) B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2(3): 269-274
  2. Castriconi, R. et al. (2004) Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc. Natl. Acad. Sci. U.S.A. 101(34): 12640-12645
  3. Chen, Y. W. et al. (2008) The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion. Curr. Cancer Drug Targets 8(5): 404-413

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