Clone:
REA1030
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFSF10, APO2L, Ly81, TL2, TRAIL

Specifications for CD253 Antibody, anti-mouse, REAfinity™

Overview

Clone REA1030 recognizes the mouse CD253 antigen, a type 2 transmembrane protein also known as TNF-related apoptosis-inducing ligand (TRAIL), APO-2 ligand (APO-2L), or TNF ligand superfamily member 10 (TNFSF10). CD253 is expressed on a variety of cells of the innate and adaptive immune system, including natural killer (NK) cells. Often expression is induced or upregulated upon activation. CD253 can trigger apoptosis through trimerization of death receptor DR5 (TRAILR).
Additional information: Clone REA1030 displays negligible binding to Fc receptors.

Alternative names

TNFSF10, APO2L, Ly81, TL2, TRAIL

Detailed product information

Technical specifications

CloneREA1030
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD253
Alternative names of antigenTNFSF10, APO2L, Ly81, TL2, TRAIL
Molecular mass of antigen [kDa]33
Distribution of antigenB cells, dendritic cells, monocytes, NK cells, T cells, thymocytes
Entrez Gene ID22035
RRIDAB_2727983, AB_2727934, AB_2727984, AB_2727935, AB_2727985, AB_2727936, AB_2727986, AB_2727937, AB_2727987, AB_2727938, AB_2727988, AB_2727989, AB_2727990, AB_2727939, AB_2727991, AB_2727940, AB_2727982

Resources for CD253 Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for CD253 Antibody, anti-mouse, REAfinity™

Publications

  1. Wiley, S. R. et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3(6): 673-682
  2. Hofmann, K. (1999) The modular nature of apoptotic signaling proteins. Cell. Mol. Life Sci. 55(8-9): 1113-1128
  3. Locksley, R. M. et al. (2001) The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104(4): 487-501

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