Clone:
REA290
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IL17RA, CANDF5, CDw217, IL-17RA, IL17R, hIL-17R

Specifications for CD217 (IL-17RA) Antibody, anti-human, REAfinity™

Overview

Clone REA290 recognizes the human CD217 antigen, a single-pass type I membrane protein which is also known as interleukin-17 receptor A (IL-17RA). CD217 is a ubiquitously expressed receptor and subsequently shown to bind interleukin 17 (IL-17) with high affinity. IL-17 is an inflammatory cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation. It also plays critical roles in the pathogenesis of multiple autoimmune diseases. CD217 forms heterodimeric complexes with several other members of its receptor family, including IL-17RC for IL-17A and IL-17F signaling and IL-17RC for IL-17E (IL-25) signaling.
Additional information: Clone REA290 displays negligible binding to Fc receptors

Alternative names

IL17RA, CANDF5, CDw217, IL-17RA, IL17R, hIL-17R

Detailed product information

Technical specifications

CloneREA290
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD217 (IL-17RA)
Alternative names of antigenIL17RA, CANDF5, CDw217, IL-17RA, IL17R, hIL-17R
Molecular mass of antigen [kDa]92
Distribution of antigenmonocytes, neutrophils
Entrez Gene ID23765
RRIDAB_2819389, AB_2656335, AB_2656336, AB_2656341, AB_2656342, AB_2656343, AB_2656344, AB_2819391

Resources for CD217 (IL-17RA) Antibody, anti-human, REAfinity™

Certificates

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References for CD217 (IL-17RA) Antibody, anti-human, REAfinity™

Publications

  1. Ding, Y. et al. (2013) IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells J. Immunol. 191(4): 1614-1624
  2. Toy, D. et al. (2006) Cutting edge: interleukin 17 signals through a heteromeric receptor complex J. Immunol. 177(1): 36-39
  3. Yao, Z. et al. (1997) Molecular characterization of the human interleukin (IL)-17 receptor Cytokine 9(11): 794-800

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