Clone:
REA735
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
HYK, STK1, TIE-2, TIE2, TEK

Specifications for CD202b (TIE-2) Antibody, anti-mouse, REAfinity™

Overview

Clone REA735 recognizes the CD202b antigen, also known as TIE-2 or TEK. CD202b is a tyrosine-protein kinase which is mainly expressed in endothelial cells and their progenitors. CD202b is a cell-surface receptor for angiopoietins and is involved in angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, and re-organization of the actin cytoskeleton.
Additional information: Clone REA735 displays negligible binding to Fc receptors.

Alternative names

HYK, STK1, TIE-2, TIE2, TEK

Detailed product information

Technical specifications

CloneREA735
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD202b (TIE-2)
Alternative names of antigenHYK, STK1, TIE-2, TIE2, TEK
Molecular mass of antigen [kDa]124
Distribution of antigenendothelial cells
Entrez Gene ID21687
RRIDAB_2656153, AB_2656154, AB_2656155, AB_2656156, AB_2656157, AB_2656152

Resources for CD202b (TIE-2) Antibody, anti-mouse, REAfinity™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD202b (TIE-2) Antibody, anti-mouse, REAfinity™

Publications

  1. Dumont, D. J. et al. (1993) The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors. Oncogene 8(5): 1293-1301
  2. Jones, N. et al. (1999) Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J. Biol. Chem. 274(43): 30896-30905
  3. Fiedler, U. et al. (2003) Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats. J. Biol. Chem. 278(3): 1721-1727

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