Clone:
RP/14
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG2aκ
Applications:
FA, FC, MICS, IF, IHC
Alternative names:
Ly78, RP105

Specifications for CD180 (RP105) Antibody, anti-mouse

Overview

Clone RP/14 recognizes CD180, a type I transmembrane protein structurally similar to Toll like receptors (TLRs), with the conserved features of TLRs, including a leucine-rich repeat extracellular domain and regions containing conserved cysteines. However, in contrast to TLRs, CD180 lacks a typical TIR domain, containing only 6 to 11 intracytoplasmic amino acids. Antibody mediated ligation of CD180 was shown to induce B cell proliferation and protection from subsequent radiation- or dexamethasone-induced apoptosis. Expression of CD180 is found on mature B cells, monocytes, macrophages, and dendritic cells. CD180 activity is dependent on physical association with a molecule called MD-1. In B cells, CD180, together with TLR4, has been shown to induce B cell proliferation in response to LPS. However, in primary myeloid cells and
in vivo
, CD180 acts as an inhibitor of TLR4 signaling.

Alternative names

Ly78, RP105

Detailed product information

Technical specifications

CloneRP/14
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD180 (RP105)
Alternative names of antigenLy78, RP105
RRIDAB_2655695, AB_2655696, AB_2655697, AB_2655698, AB_2655699, AB_2655700, AB_2655701, AB_2655702, AB_2661341

Resources for CD180 (RP105) Antibody, anti-mouse

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for CD180 (RP105) Antibody, anti-mouse

Publications

  1. Divanovic, S. et al. (2007) Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105. J. Leukoc. Biol. 82: 265-271
  2. Divanovic, S. et al. (2005) Inhibition of TLR-4/MD-2 signaling by RP105/MD-1. J. Endotoxin Res. 11: 363-368

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