Clone:
REA252
Type of antibody:
Recombinant antibodies, Primary antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1

Specifications for CD120a (TNF-RI) Antibody, anti-human, REAfinity™

Overview

Clone REA252 recognizes the extracellular part of the membrane-bound and soluble form of the CD120a antigen, a 55 kDa type I transmembrane glycoprotein also known as tumor necrosis factor receptor type I (TNF-RI) or p55. CD120a belongs to the TNF receptor superfamily and is mainly expressed by monocytes, macrophages, and neutrophils. It is also expressed by a variety of cell lines, tumor cells, and normal cell types including T cells, endothelial cells, hepatocytes, chondrocytes, and fibroblasts. Binding of TNF-α to its main receptor CD120a triggers signaling which is extremely complex, leading to both cell death and survival signals. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of human diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease.
Additional information: Clone REA252 displays negligible binding to Fc receptors.

Alternative names

TNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1

Detailed product information

Technical specifications

CloneREA252
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyRecombinant antibodies, Primary antibodies
Specieshuman
AntigenCD120a (TNF-RI)
Alternative names of antigenTNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1
Molecular mass of antigen [kDa]48
Distribution of antigengranulocytes, monocytes, macrophages, T cells, chondrocytes, endothelial cells, fibroblasts, neutrophils, liver
Entrez Gene ID7132
RRIDAB_2783923, AB_2752062, AB_2752049, AB_2654726, AB_2654727, AB_2654728, AB_2654729, AB_2783924

Resources for CD120a (TNF-RI) Antibody, anti-human, REAfinity™

Certificates

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References for CD120a (TNF-RI) Antibody, anti-human, REAfinity™

Publications

  1. Grell, M. et al. (1998) The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. U.S.A. 95: 570-575
  2. Bianchi, K. et al. (2009) A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. Mol. Cell 36(5): 736-742
  3. Hijdra, D. et al. (2012) Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes. J. Inflamm. 9(1): 38

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