Clone:
REA211
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, FC
Alternative names:
CSF2RA, GM-CSF-R-α

Specifications for CD116 Antibody, anti-human, REAfinity™

Overview

Clone REA211 recognizes CD116, the α subunit of GM-CSF receptor, which serves as a receptor for GM-CSF cytokine. GM-CSF is involved in innate and adaptive immune responses to infection, stimuli such as presence of LPS, and inflammatory diseases, such as asthma, rheumatoid arthritis, and multiple sclerosis. The GM-CSF receptor comprises of cytokine-specific α subunit, CD116, and βc subunit, which is a common subunit shared by interleukin-3 (IL-3) and IL-5. The human CD116 is a 378 residue glycoprotein with an extracellular N-terminal Ig-like domain, two fibronectin (FnIII) domains, and a 54 residue intracellular domain. Expression of CD116 is found on myeloid cells including monocytes, macrophages, neutrophils, eosinophils, dendritic cells, fibroblasts, endothelial cells, and myeloid leukemias.
Additional information: Clone REA211 displays negligible binding to Fc receptors.

Alternative names

CSF2RA, GM-CSF-R-α

Detailed product information

Technical specifications

CloneREA211
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD116
Alternative names of antigenCSF2RA, GM-CSF-R-α
Distribution of antigenendothelial cells, macrophages, monocytes, dendritic cells, fibroblasts
RRIDAB_2654562, AB_2654563, AB_2654564, AB_2654565, AB_2654566, AB_2654567, AB_2654568, AB_2654569, AB_2654570, AB_2654571, AB_2654572, AB_2654573, AB_2654574, AB_2654575, AB_2819668

Resources for CD116 Antibody, anti-human, REAfinity™

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for CD116 Antibody, anti-human, REAfinity™

Publications

  1. Kared, H. et al. (2008) Role of GM-CSF in tolerance induction by mobilized hematopoietic progenitors. Blood 112: 2575-2578
  2. Matsuguchi, T. et al. (1997) The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor subunit is essential for both GM-CSF-mediated growth and differentiation. J. Biol. Chem. 272: 17450-17459

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CD116 Antibody, anti-human, REAfinity™

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