Clone:
REA392
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Vtcn1, B7h4, B7S1, B7x, BC032925

Specifications for B7-H4 Antibody, anti-mouse, REAfinity™

Overview

Clone REA392 recognizes the mouse B7-H4 antigen, a glycosylphosphatidylinositol (GPI) linked protein which is also known as V-set domain containing T-cell activation inhibitor 1 (Vtcn1). The B7 family of T cell costimulatory and coinhibitory molecules plays a pivotal role in the regulation of adaptive immune responses. As such, B7-H4 was identified as a coinhibitory member of the B7 family. In mice, B7-H4 expression is limited to B cells and APCs. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. It has also been shown to negatively regulate neutrophil-mediated innate immune responses. Apart from the immune system, B7-H4 is overexpressed on some tumor cancer cells. When expressed on the cell surface of tumor macrophages, B7-H4 plays an important role, together with regulatory T-cells, in the suppression of tumor-associated antigen-specific T-cell immunity.
Additional information: Clone REA392 displays negligible binding to Fc receptors.

Alternative names

Vtcn1, B7h4, B7S1, B7x, BC032925

Detailed product information

Technical specifications

CloneREA392
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenB7-H4
Alternative names of antigenVtcn1, B7h4, B7S1, B7x, BC032925
Molecular mass of antigen [kDa]26
Distribution of antigenB cells, monocytes, dendritic cells, macrophages
Entrez Gene ID242122
RRIDAB_2651244, AB_2651245, AB_2651246, AB_2651247, AB_2651248, AB_2651249, AB_2651250, AB_2651251, AB_2651252, AB_2651253

Resources for B7-H4 Antibody, anti-mouse, REAfinity™

Certificates

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References for B7-H4 Antibody, anti-mouse, REAfinity™

Publications

  1. Leung, J. et al. (2013) Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J. Immunol. 190(12): 6651-6661
  2. Sica, G. L. et al. (2003) B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18(6): 849-861
  3. Zhu, G. et al. (2009) B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood 113(8): 1759-1767

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