Clone:
1E6.4
Type of antibody:
Primary antibodies
Isotype:
rat IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Specifications for AN2 Antibody, anti-human/mouse

Overview

AN2 is the mouse homolog of the rat NG2 and human MCSP proteins. NG2 is a chondroitin sulfate glycoprotein that is expressed by glial progenitor cells in the developing and adult central nervous system (CNS) and by immature Schwann cells. NG2/AN2
+
glia has been identified as a fourth major glial cell type in the mammalian CNS that is distinct from other cell types. NG2/AN2
+
cells are precursors of oligodendrocytes and some protoplasmic astrocytes in the gray matter. NG2/AN2 expression is down-regulated before the cells undergo terminal differentiation. However, a population of NG2/AN2
+
cells remains in the white and gray matter after oligodendrocytes are generated. NG2/AN2
+
glial cells participate in neuron-glial circuits by receiving presynaptic input from neurons and responding to neurotransmitters released by synapses. Many highly migratory neural tumors including melanomas express NG2/AN2.

Alternative names

CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Detailed product information

Technical specifications

Clone1E6.4
Clonalitymonoclonal
Isotyperat IgG1
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies
Specieshuman, mouse
AntigenAN2
Alternative names of antigenCSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
Molecular mass of antigen [kDa]248
Entrez Gene ID1464
RRIDAB_2651233, AB_2651234, AB_2651235

Resources for AN2 Antibody, anti-human/mouse

Certificates

Please follow this
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to search for Certificates of Analysis (CoA) by lot number.

References for AN2 Antibody, anti-human/mouse

Publications

  1. Trotter, J. et al. (2010) NG2 cells: Properties, progeny and origin. Brain Res. Rev. 63: 72-82
  2. Zhu, X. et al. (2008) NG2 cells generate both oligodendrocytes and gray matter astrocytes. Development 132: 145-157
  3. Zhu, X. et al. (2011) Age-dependent fate and lineage restriction of single NG2 cells. Development 138: 745-753
  4. Diers-Fenger, M. et al. (2001) AN2/NG2 protein-expressing glial progenitor cells in the murine CNS: isolation, differentiation, and association with radial glia. Glia 34: 213-228
  5. Wigley, R. et al. (2007) Morphological and physiological interactions of NG2-glia with astrocytes and neurons. J. Anat. 210: 661-670
  6. Stegmuller, J. et al. (2002) AN2, the mouse homologue of NG2, is a surface antigen on glial precursor cells implicated in control of cell migration. J. Neurocytol. 31: 497-505
  7. Peters, A. (2004) A fourth type of neuroglial cell in the adult central nervous system. J. Neurocytol. 33: 345-357
  8. Nishiyama, A. et al. (2009) Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity. Nat. Rev. Neurosci. 10: 9-22

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