Clone:
W8B2
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP

Specifications for MSCA-1 Antibody, anti-human

Overview

Clone W8B2 recognizes the mesenchymal stromal cell antigen-1 (MSCA-1). MSCA-1 was shown to be restricted to mesenchymal stromal cells (MSCs) in the CD271
bright
population in bone marrow. These CD271
bright
CD45
dim
MSCs have a much higher clonogenic capacity compared to the CD271
+
CD45
+
fraction in bone marrow. Therefore, MSCA-1 is a suitable marker to identify MSCs with a high proliferative potential. MSCA-1 expression was not found on placenta-derived MSCs after culture.

Alternative names

ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP

Detailed product information

Technical specifications

CloneW8B2
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman, non-human primate, other
Cross-reactivitydog, pig, sheep, goat, monkey
AntigenMSCA-1
Alternative names of antigenALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP
Molecular mass of antigen [kDa]53
Entrez Gene ID249
RRIDAB_10827708, AB_2660803, AB_10828919, AB_10839568, AB_10830716, AB_2660802

References for MSCA-1 Antibody, anti-human

Publications

  1. Bühring, H. J. et al. (2007) Novel markers for the prospective isolation of human MSC. Ann. N. Y. Acad. Sci. 1106: 262-271
  2. Battula, V. L. et al. (2007) Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation 75: 279-291
  3. Rozemuller, H. et al. (2010) Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem Cells Dev. 19: 1911-1921

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