Effective polyclonal T cell activation and expansion

Polyclonal activation and expansion of T cells serves to generate large numbers of effector cells and may be required to improve gene modification, for example, during cell manufacturing processes. Miltenyi Biotec’s nano-sized polymeric matrix T Cell TransAct™, soluble antibodies, and antibody-coated cell-sized particles (ExpAct™ Treg Kit) are well suited to achieve an effective polyclonal T cell stimulation and expansion in vitro. Conjugated to humanized recombinant CD3 and CD28 agonists, the nanomatrix MACS GMP T Cell TransAct can be sterile filtered and is tailor-made for the use in automated culture performed with the CliniMACS Prodigy® Instrument.

For complete regulatory notes click here.