MACS GMP Vectofusin-1 is a non-toxic histidin-rich amphipathic peptide which exerts as viral transduction enhancer. Unlike other transduction enhancers, it is not dependent on immobilization of target cells and therefore compatible with automated processes.

Specifications for
MACS
®
GMP Vectofusin
®
-1

Overview

MACS GMP Vectofusin-1 is a non-toxic histidin-rich amphipathic peptide which exerts as viral transduction enhancer. Unlike other transduction enhancers, it is not dependent on immobilization of target cells and therefore compatible with automated processes.

Detailed product information

Background information

Viral transduction of suspension cells using retroviral vectors is often inefficient and requires the use of transduction enhancers. MACS GMP Vectofusin-1 is a fully synthetic, non-toxic, cationic amphipathic peptide with viral transduction enhancing capacity, enabling higher transduction levels with low amounts of retroviral vector. MACS GMP Vectofusin-1 promotes the entry of several retroviral pseudo-types into target cells when added to the culture medium.

Applications

  • Enhancement of lentiviral transduction
  • Enhancement of retroviral transduction

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Disclaimer

MACS GMP Products are for research use and
ex vivo
cell culture processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Resources for
MACS
®
GMP Vectofusin
®
-1

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for
MACS
®
GMP Vectofusin
®
-1

Publications

  1. Fenard, D. et al. (2013) Infectivity enhancement of different HIV-1-based lentiviral pseudotypes in presence of the cationic amphipathic peptide LAH4-L1. J. Virol. Methods 189(2): 375-378