StemMACS™ Y27632 is a selective small molecule inhibitor of Rho-associated kinase (ROCK).

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Chemical structure of StemMACS™ Y27632
Chemical structure of StemMACS™ Y27632

Specifications for StemMACS™ Y27632

Overview

StemMACS™ Y27632 is a selective small molecule inhibitor of Rho-associated kinase (ROCK).

Detailed product information

Background information

Rho-associated kinase is found in two isoforms, ROCK I (p160ROCK, ROCKβ) and ROCK II (ROCKα), both of which are inhibited by Y27632. The inhibition is reversible and competitive with respect to ATP.

Applications

Published applications for Y27632 include:
  • Improved survival of human pluripotent stem cells after dissociation into single cells, e.g. during cell passaging or cell separation1
  • Improved survival after thawing2

Resources for StemMACS™ Y27632

Documents and Protocols

References for StemMACS™ Y27632

Publications

  1. Watanabe, K. et al. (2007) A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25: 681-686
  2. Li, X. et al. (2009) ROCK inhibitor improves survival of cryopreserved serum/feeder-free single human embryonic stem cells. Hum. Reprod. 24: 580-589

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StemMACS™ Y27632

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