StemMACS™ Thiazovivin is a selective small molecule inhibitor of Rho-associated kinase (ROCK).

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Chemical structure of StemMACS™ Thiazovivin
Chemical structure of StemMACS™ Thiazovivin

Specifications for StemMACS™ Thiazovivin

Overview

StemMACS™ Thiazovivin is a selective small molecule inhibitor of Rho-associated kinase (ROCK).

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Background information

StemMACS™ Thiazovivin is a selective small molecule inhibitor of Rho-associated Kinase (ROCK). Thiazovivin promotes survival and cloning efficiency of human pluripotent stem cells after enzymatic dissociation into single cells. It has been shown to increase reprogramming efficiency when combined with inhibitors of the TGF-β and MEK signaling pathways.

Applications

Published applications for Thiazovivin include:
  • Modulation of E-Cadherin signaling in human ES cells1
  • Increase of reprogramming efficiency in combination with PD0325901 and SB4315422

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References for StemMACS™ Thiazovivin

Publications

  1. Xu, Y. et al. (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc. Natl. Acad. Sci. U.S.A. 107(18): 8129-8134
  2. Lin, T. et al. (2009) A chemical platform for improved induction of human iPSCs. Nat. Methods 6: 805-808

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