Clone:
REA864
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
SIT

Specifications for SIT1 Antibody, anti-human, REAfinity™

Overview

Clone REA864 recognizes the human SIT1 antigen, a disulfide-linked homodimeric glycoprotein also known as SHP2 interacting transmembrane adaptor protein or suppression-inducing transmembrane adapter 1. SIT1 is expressed in lymphocytes and predominantly found in T and B cells as well as in plasma cells.
SIT1 plays a regulatory role in T cell activation and development. In association with Grb2 and SHP2, it is involved in signal transduction.
Additional information: Clone REA864 displays negligible binding to Fc receptors.

Alternative names

SIT

Detailed product information

Technical specifications

CloneREA864
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Cross-reactivitymouse
AntigenSIT1
Alternative names of antigenSIT
Molecular mass of antigen [kDa]19
Distribution of antigenlymphocytes, T cells, B cells
Entrez Gene ID27240
RRIDAB_2653469, AB_2653470, AB_2653471, AB_2653472, AB_2653473, AB_2653474, AB_2653475, AB_2653468

References for SIT1 Antibody, anti-human, REAfinity™

Publications

  1. Marie-Cardine, A. et al. (1999) SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J. Exp. Med. 189(8): 1181-1194
  2. Tedoldi, S. et al. (2006) Transmembrane adaptor molecules: a new category of lymphoid-cell markers. Blood 107(1): 213-221

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