Clone:
REA1178
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC, 3D-IF
Alternative names:
orthodenticle 2

Specifications for OTX2 Antibody, anti-human, REAfinity™

Overview

Clone REA1178 recognizes the human orthodenticle 2 (OTX2) protein, which is a member of the bicoid sub-family of homeodomain-containing transcription factors. OTX2 is expressed on pluripotent stem cells and differentiated cells in brain, ear, nose, and eye. It plays an essential role in proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis and is involved in brain, craniofacial, and sensory organ development.
Additional information: Clone REA1178 displays negligible binding to Fc receptors.

Alternative names

orthodenticle 2

Detailed product information

Technical specifications

CloneREA1178
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenOTX2
Alternative names of antigenorthodenticle 2
Molecular mass of antigen [kDa]32
Distribution of antigenstem cells, other, brain, eye
Entrez Gene ID5015
RRIDAB_2801805, AB_2801809, AB_2801806, AB_2801810, AB_2801807, AB_2801808

References for OTX2 Antibody, anti-human, REAfinity™

Publications

  1. Nagao, T. et al. (1998)
    Developmental rescue of
    Drosophila cephalic
    defects by the human OTX genes.
    Proc. Natl. Acad. Sci. U.S.A. 95(7): 3737-3742
  2. Gorbenko Del Blanco, D. et al. (2012) A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation, and an underdeveloped left optic nerve. Eur. J. Endocrinol. 167(3): 441-452

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