Clone:
LT27:295
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1, mouse IgG1κ
Applications:
MC, ICFC
Alternative names:
IFNA1

Specifications for IFN-α Antibody, anti-human

Overview

Type I interferons (IFNs), including IFN-α, are a family of cytokines that exert pleiotropic functions in the immune system. Besides its potent antiviral activity, IFN-α exerts a variety of immunomodulatory effects, including positive and negative regulation of its own production, regulation of IL-12 and IFN-γ production, promotion of natural killer (NK) cell cytotoxicity, activation and maturation of dendritic cells, and the promotion of B cell development towards plasma cells. IFN-α is expressed predominantly by CD123
+
CD11c
-
CD303 (BDCA2)
+
plasmacytoid dendritic cells (pDCs). Clone LT27:295 recognizes the majority of the IFN-α subtypes, including IFN-α2b.

Alternative names

IFNA1

Detailed product information

Technical specifications

CloneLT27:295
Clonalitymonoclonal
Isotypemouse IgG1κ, mouse IgG1
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenIFN-α
Alternative names of antigenIFNA1
Molecular mass of antigen [kDa]19-20
Entrez Gene ID3439, 3440, 3451, 3445, 3447, 3452, 3441, 3446, 3448, 3442
RRIDAB_2659983, AB_871558, AB_871557, AB_2659989

References for IFN-α Antibody, anti-human

Publications

  1. Båve, U. et al. (2003) FcγRIIa is expressed on natural IFN-α-producing cells (plasmacytoid dendritic cells) and is required for the IFN-α production induced by apoptotic cells combined with lupus IgG. J. Immunol. 171: 3296-3302
  2. Ronnblom, L. and Alm, G. V. (2001) An etiopathogenic role for the type I IFN system in SLE. Trends Immunol. 22: 427-431

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