Clone:
REA732
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
NFIL3

Specifications for E4BP4 (NFIL3) Antibody, anti-human, REAfinity™

Overview

Clone REA732 recognizes the human E4BP4 (NFIL3) antigen, a basic leucine zipper transcription factor that is regulated by the cytokine IL-3. E4BP4 is highly expressed in lung and in lower levels in brain and spinal cord. E4BP4 acts with members of the PAR family of transcription factors with which it shares DNA-binding specificity. It plays a role in commitment to cell survival versus apoptosis, anti-inflammatory response, and transcriptional controlling of the mammalian circadian clock. Furthermore, E4BP4 plays an essential role in the development of CD8α
+
conventional dendritic cells (cDCs).
Additional information: Clone REA732 displays negligible binding to Fc receptors.

Alternative names

NFIL3

Detailed product information

Technical specifications

CloneREA732
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenE4BP4 (NFIL3)
Alternative names of antigenNFIL3
Molecular mass of antigen [kDa]52
Distribution of antigenother, bladder, bone marrow, lymph node, muscle, testicle, trachea
Entrez Gene ID4783
RRIDAB_2651592, AB_2651593, AB_2651594, AB_2651591

References for E4BP4 (NFIL3) Antibody, anti-human, REAfinity™

Publications

  1. Kashiwada, M. et al. (2011) NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development. Blood 117(23): 6193-6197
  2. Cowell, I. G. (2002) E4BP4/NFIL3, a PAR-related bZIP factor with many roles. Bioessays 24(11): 1023-1029
  3. Hulme, D. J. et al. (2000) Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis. Hum. Genet. 106(6): 594-596

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