Clone:
DCN47.5
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC, MICS, IF, IHC
Alternative names:
CDSIGN, CLEC4L, DC-SIGN

Specifications for CD209 (DC-SIGN) Antibody, anti-human

Overview

Clone DCN47.5 recognizes CD209 (Dendritic Cell Specific ICAM-3 Grabbing Non-integrin, DC-SIGN), a type II c-type lectin expressed in dermal and mucous tissue, lymphoid tissue such as tonsil, lymph node, spleen, and on monocyte-derived DCs (MoDCs). It is not expressed on DC subsets in peripheral blood, except for a subpopulation of CD14
+
cells with a DC-like phenotype.
DC-SIGN acts as an adhesion receptor to facilitate interactions between DCs and T cells or DCs and endothelial cells. In addition, it serves as an antigen receptor mediating internalization of ligands for antigen presentation, binding virus such as HIV, HCMV, or Ebola as well as parasites, bacteria, or yeast.
HIV-1 uses this feature of DC-SIGN for efficient in
-trans
infection of CD4
+
T cells.

Alternative names

CDSIGN, CLEC4L, DC-SIGN

Detailed product information

Technical specifications

CloneDCN47.5
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenCD209 (DC-SIGN)
Alternative names of antigenCDSIGN, CLEC4L, DC-SIGN
Molecular mass of antigen [kDa]46
Distribution of antigendendritic cells, endothelial cells, macrophages, skin, spleen
Entrez Gene ID30835
RRIDAB_871642, AB_2660243, AB_871643, AB_2660244, AB_871640, AB_2660245, AB_2660246, AB_2660247, AB_2660248, AB_2660249, AB_2660250, AB_871641, AB_871639, AB_2660242

References for CD209 (DC-SIGN) Antibody, anti-human

Publications

  1. Geijtenbeek, T. B. et al. (2000) Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 100: 575-585
  2. Koppel, E. A. et al. (2005) Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation. Cell. Microbiol. 7: 157-165

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