Clone:
REA356
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
BCL2, Apoptosis regulator Bcl-2

Specifications for Bcl-2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA356 recognizes the mouse Bcl-2 antigen, a 26 kDa intracellular single-pass membrane protein found primarily in the mitochondrion outer membrane, the nucleus membrane, and the endoplasmic reticulum membrane. Bcl-2 is the founding member of the Bcl-2 family of regulator proteins and it forms homodimers or heterodimers with other Bcl-2 family members. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability and it appears to function in a feedback loop system with caspases. Caspase activity is either inhibited by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor.
Additional information: Clone REA356 displays negligible binding to Fc receptors.

Alternative names

BCL2, Apoptosis regulator Bcl-2

Detailed product information

Technical specifications

CloneREA356
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenBcl-2
Alternative names of antigenBCL2, Apoptosis regulator Bcl-2
Molecular mass of antigen [kDa]26
Distribution of antigenother
Entrez Gene ID12043
RRIDAB_2651268, AB_2651269, AB_2751555

References for Bcl-2 Antibody, anti-mouse, REAfinity™

Publications

  1. Dunkle, A. et al. (2013)
    Transfer of CD8
    +
    T cell memory using Bcl-2 as a marker.
    J. Immunol. 190(3): 940-947
  2. Czabotar, P. E. et al. (2014) Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat. Rev. Mol. Cell Biol. 15(1): 49-63
  3. Negrini, M. et al. (1987) Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell 49(4): 455-463

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