Clone:
REA486
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
B-ATF1, SFA-2, SFA2, B-ATF

Specifications for BATF Antibody, anti-human, REAfinity™

Overview

Clone REA486 recognizes the human B cell–activating transcription factor (BATF) antigen, a 14 kDa transcription factor belonging to the AP-1 family of basic leucine zipper transcription factors. BATF plays an important role in regulating differentiation and function in many lymphocyte lineages. In the CD8
+
T cell lineage, increased expression of BATF in exhausted CD8
+
T cells suppresses their effector function. In the CD4
+
T cell lineage, BATF is required for the differentiation of interleukin 17 producing helper T cells, where it binds cooperatively with the transcription factor IRF4 and its dimerization partners c-Jun, JunB, and JunD. BATF is also important for the development of follicular helper T cells by regulating the transcription factors Bcl-6 and c-Maf. In addition, BATF is required for class-switch recombination in B cells and to regulate activation-induced cytidine deaminase as well as DNA damage checkpoint in hematopoietic stem cell self-renewal.
Additional information: Clone REA486 displays negligible binding to Fc receptors.

Alternative names

B-ATF1, SFA-2, SFA2, B-ATF

Detailed product information

Technical specifications

CloneREA486
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenBATF
Alternative names of antigenB-ATF1, SFA-2, SFA2, B-ATF
Molecular mass of antigen [kDa]14
Distribution of antigenB cells, T cells, leukocytes, T helper cells
Entrez Gene ID10538
RRIDAB_2651258, AB_2651259, AB_2651260, AB_2651261, AB_2651262, AB_2651263

References for BATF Antibody, anti-human, REAfinity™

Publications

  1. Li, P. et al. (2012) BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature 490(7421): 543-546
  2. Kurachi, M. et al. (2014)
    The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8
    +
    T cells.
    Nat. Immunol. 15(4): 373-383
  3. Dorsey, M. J. et al. (1995) B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family. Oncogene 11(11): 2255-2265

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