Name: β-Catenin Antibody, anti-human/mouse, REAfinity™
Availability: InStock

Intracellular flow cytometry

Conjugate:	PE
Recommended dilution:	1:50
Remark:	The antibody is suited for staining of formaldehyde-fixed cells.
Tested:	QC tested
Products used:	130-122-006, 130-121-990

Specifications for β-Catenin Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA480 recognizes the human and mouse β-catenin antigen, a 92 kDa dual function protein regulating the coordination of cell-cell adhesion and gene transcription. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. As a component of adherens junctions, β-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor adenomatous polyposis coli (APC). Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors as well as ovarian and endometrial cancer.

Additional information: Clone REA480 displays negligible binding to Fc receptors.

Alternative names

CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb

Detailed product information

Technical specifications

Clone	REA480
Clonality	monoclonal
Isotype	recombinant human IgG1
Isotype control	REA Control Antibody (I), human IgG1
Host	cell line
Type of antibody	Primary antibodies, Recombinant antibodies
Species	human, mouse
Antigen	β-Catenin
Alternative names of antigen	CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb
Molecular mass of antigen [kDa]	85
Distribution of antigen	endothelial cells, epithelial cells, fibroblasts, keratinocytes
Entrez Gene ID	1499, 12387
RRID	AB_2784494, AB_2811667, AB_2811666, AB_2784495

References for β-Catenin Antibody, anti-human/mouse, REAfinity™

Publications

Butz, S. et al. (1992) Plakoglobin and beta-catenin: distinct but closely related. Science 257(5073): 1142-1144
Clevers, H. et al. (2012) Wnt/β-catenin signaling and disease. Cell 149(6): 1192-1205
MacDonald, B. T. et al. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17(1): 9-26

Applications

Specifications

Specifications for β-Catenin Antibody, anti-human/mouse, REAfinity™

Overview

Additional information: Clone REA480 displays negligible binding to Fc receptors.

Alternative names

CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb

Detailed product information

Technical specifications

Clone	REA480
Clonality	monoclonal
Isotype	recombinant human IgG1
Isotype control	REA Control Antibody (I), human IgG1
Host	cell line
Type of antibody	Primary antibodies, Recombinant antibodies
Species	human, mouse
Antigen	β-Catenin
Alternative names of antigen	CTNNB1, CTNNB, MRD19, armadillo, CTNB1, Beta-catenin, Catnb
Molecular mass of antigen [kDa]	85
Distribution of antigen	endothelial cells, epithelial cells, fibroblasts, keratinocytes
Entrez Gene ID	1499, 12387
RRID	AB_2784494, AB_2811667, AB_2811666, AB_2784495

References

References for β-Catenin Antibody, anti-human/mouse, REAfinity™

Publications

Butz, S. et al. (1992) Plakoglobin and beta-catenin: distinct but closely related. Science 257(5073): 1142-1144
Clevers, H. et al. (2012) Wnt/β-catenin signaling and disease. Cell 149(6): 1192-1205
MacDonald, B. T. et al. (2009) Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev. Cell 17(1): 9-26

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β-Catenin Antibody, anti-human/mouse, REAfinity™

β-Catenin Antibody, anti-human/mouse, REAfinity™

Intracellular flow cytometry

Specifications for β-Catenin Antibody, anti-human/mouse, REAfinity™

Overview

Alternative names

Detailed product information

Technical specifications

References for β-Catenin Antibody, anti-human/mouse, REAfinity™

Publications

Specifications for β-Catenin Antibody, anti-human/mouse, REAfinity™

Overview

Alternative names

Detailed product information

Technical specifications

References for β-Catenin Antibody, anti-human/mouse, REAfinity™

Publications

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β-Catenin Antibody, anti-human/mouse, REAfinity™