Clone:
A7R 34
Type of antibody:
Primary antibodies, Functional-grade antibodies
Isotype:
rat IgG2aκ
Applications:
FC, MICS, IF, IHC, FA
Alternative names:
IL-7R, IL-7Rα

Specifications for CD127 Antibody, anti-mouse

Overview

The antibody clone A7R 34 reacts with CD127, also known as interleukin 7 receptor α chain (IL-7Rα). Mouse CD127 is a 60–90 kDa type I transmembrane glycoprotein. It is a component of the high affinity IL-7 receptor (IL-7R) and the receptor for thymic stromal lymphopoietin (TSLP). CD127 is expressed on immature B cells, CD4
-
CD8
-
, CD4
+
, and CD8
+
thymocytes, naive and memory T cells, thymic NK cells, and bone marrow stromal cells. Upon activation of naive T cells, CD127 expression is down-regulated. Re-expression of CD127 identifies the effector cells that will differentiate into memory T cells.

Alternative names

IL-7R, IL-7Rα

Detailed product information

Technical specifications

CloneA7R 34
Clonalitymonoclonal
Isotyperat IgG2aκ
Isotype controlIsotype Control Antibody, rat IgG2a
Hostrat
Type of antibodyPrimary antibodies, Functional-grade antibodies
Speciesmouse
AntigenCD127
Alternative names of antigenIL-7R, IL-7Rα
Molecular mass of antigen [kDa]50
Distribution of antigenB cells, monocytes, T cells, lymphocytes, thymocytes, bone marrow, liver
Entrez Gene ID16197
RRIDAB_2660822, AB_2811314, AB_2819747, AB_10839703, AB_2660821, AB_2727576

Resources for CD127 Antibody, anti-mouse

References for CD127 Antibody, anti-mouse

Publications

  1. Colpitts, S. L. et al. (2009)
    IL-7 receptor expression provides the potential for long-term survival of both CD62L
    high
    central memory T cells and Tʜ1 effector cells during
    Leishmania major
    infection.
    J. Immunol. 182: 5702-5711
  2. Vosshenrich, C. A. et al. (2006) A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat. Immunol. 7: 1217-1224
  3. Kaech, S. M. et al. (2003) Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4: 1191-1198
  4. Park, L. S. et al. (2000) Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J. Exp. Med. 192(5): 659-670
  5. Sudo, T. et al. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 90: 9125-9129
  6. Goodwin, R. G. et al. (1990) Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 60: 941-951

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CD127 Antibody, anti-mouse

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