FcR Blocking Reagent, mouse

Incubation of cells with FcR Blocking Reagent, mouse, increases the specificity of labeling with MACS® Antibodies or MACS MicroBeads and thereby improves the specificity of immunofluorescent staining and purity of magnetically isolated target cells, respectively.

Specifications for FcR Blocking Reagent, mouse

Overview

Incubation of cells with FcR Blocking Reagent, mouse, increases the specificity of labeling with MACS® Antibodies or MACS MicroBeads and thereby improves the specificity of immunofluorescent staining and purity of magnetically isolated target cells, respectively.

Detailed product information

Applications

FcR Blocking Reagent, mouse is used to block unwanted binding of antibodies to mouse cells expressing Fc receptors, such as B cells, monocytes, and macrophages. It thereby increases the specificity of MicroBead labeling to rare cells, for example, neural stem cells, hematopoietic stem cells, or regulatory T cells.

Resources for FcR Blocking Reagent, mouse

Documents and Protocols

App notes/customer reports

Flow cytometry: Antibodies and controls

Reviews for FcR Blocking Reagent, mouse

Mouse FcR Blocking Antibody Review

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FcR Blocking Reagent, mouse (130-092-575)

One of the models that we have generated expresses three transgenic human host factors that allows successful acute HIV infection in these mice. We isolate different cell populations to study vaccine-induced immune responses and perform detailed FACS analysis. Some of these populations, such as NK cells and monocytes have high FcR expression, so this blocking reagent is helpful to block unspecific staining.

Mouse Fc Receptor Blocking Reagent

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FcR Blocking Reagent, mouse (130-092-575)

Our lab has developed a transgenic mouse model to study HIV. In one of our experiments we isolate regulatory T cells from mice that have been HIV infected in order to study the adaptive immune response in these mice. We use the Fc block to block unwanted binding of beads to cells expressing Fc receptor therefore increasing the yield and purity of isolated T cells.

FcR Blocking Reagent For Flow Cytometry

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FcR Blocking Reagent, mouse (130-092-575)

Our lab routinely performs multicolor flow cytometry on immune cells which requires FcR block to prevent non-specific staining of cells with FcRs. This reagent has proven to be useful and reliable in that matter.

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