Clone:
M3/84
Type of antibody:
Primary antibodies
Isotype:
rat IgG1κ
Applications:
ICFC, MICS, IF, IHC
Alternative names:
LAMP-2, LGP-B, Lamp II, Mac3

Specifications for CD107b Antibody, anti-mouse

Overview

Clone M3/84 recognizes the mouse CD107b antigen, a highly glycosylated 110 kD Single-pass type I membrane protein also known as Lysosome-associated membrane protein-2 (LAMP-2) or Mac-3 antigen. It is widely located in lysosomal membranes and the plasma membrane of macrophages and some myeloid cell lines. Under certain circumstances, e.g., after platelet activation, during granulocytic differentiation and activation, in malignant carcinoma cells, and in cytotoxic T lymphocytes, it is also found at the cell surface. CD107b has been described as a receptor for the selective import and degradation of cytosolic proteins in the lysosome, or chaperone-mediated autophagy.

Alternative names

LAMP-2, LGP-B, Lamp II, Mac3

Detailed product information

Technical specifications

CloneM3/84
Clonalitymonoclonal
Isotyperat IgG1κ
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD107b
Alternative names of antigenLAMP-2, LGP-B, Lamp II, Mac3
Molecular mass of antigen [kDa]43
Distribution of antigenmacrophages
Entrez Gene ID16784
RRIDAB_2654515, AB_2654516, AB_2654517, AB_2654518, AB_2654519, AB_2654520, AB_2654521, AB_2654522, AB_2654523, AB_2654524

Resources for CD107b Antibody, anti-mouse

References for CD107b Antibody, anti-mouse

Publications

  1. Tanaka, Y. et al. (2000) Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature 406(6798): 902-906
  2. Cha, Y. et al. (1990) The cDNA sequence of mouse LAMP-2. Evidence for two classes of lysosomal membrane glycoproteins. J. Biol. Chem. 265(9): 5008-5013
  3. Asaoka, Y. et al. (2013) Immunohistochemistry of LAMP-2 and adipophilin for phospholipidosis in liver and kidney in ketoconazole-treated mice. Exp. Toxicol. Pathol. 65(6): 817-823

Related products for
CD107b Antibody, anti-mouse

3 products available