Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
INPP5D, SHIP, SIP-145, hp51CN, p150Ship, SHIP1

Specifications for SHIP-1 Antibody, anti-human/mouse, REAfinity™


Clone REA580 recognizes the human and mouse SHIP-1 antigen, which is a 145 kDa protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. SHIP-1, also known as enzyme phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, is expressed on hematopoietic cells, including immature CD34
cells, the majority of T cells, and a minority of B cells. It has a negative effect on cell growth and therefore loss or modification may have profound effects on hematopoietic cell development. Thus SHIP-1 functions as a negative regulator of myeloid cell proliferation and survival.
Additional information: Clone REA580 displays negligible binding to Fc receptors.

Alternative names

INPP5D, SHIP, SIP-145, hp51CN, p150Ship, SHIP1

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Alternative names of antigenINPP5D, SHIP, SIP-145, hp51CN, p150Ship, SHIP1
Molecular mass of antigen [kDa]133, 134(separately shown for human and mouse/rat)
Distribution of antigenB cells, T cells, hematopoietic stem and progenitor cells
Entrez Gene ID3635, 16331
RRIDAB_2653407, AB_2653408, AB_2653409, AB_2653406

Resources for SHIP-1 Antibody, anti-human/mouse, REAfinity™


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References for SHIP-1 Antibody, anti-human/mouse, REAfinity™


  1. Geier, S. J. et al. (1997) The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood. Blood 89(6): 1876-1885
  2. Ware, M. D. et al. (1996) Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation. Blood 88(8): 2833-2840
  3. Drayer, A. L. et al. (1996) Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Biochem. Biophys. Res. Commun. 225(1): 243-249

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