Clone:
REA495
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
ABCB1, ABC20, CLCS, GP170, MDR-1, P-GP, PGY1

Specifications for CD243 (ABCB1) Antibody, anti-human, REAfinity™

Overview

Clone REA495 recognizes the human CD243 antigen, a multi-pass membrane protein which is also known as multidrug resistance protein 1 (MDR1), ATP-binding cassette sub-family B member 1 (ABCB1), or P-glycoprotein 1. CD243 is a member of the ATP-binding cassette (ABC) transporter superfamily and plays an important role in the development of multidrug resistance (MDR) in cancer cells. This transporter utilizes energy from ATP hydrolysis for the efflux of a variety of chemically dissimilar amphipathic compounds, including anticancer drugs. CD243 is extensively distributed and expressed in the intestinal epithelium, in liver cells, in the cells of the proximal tubule of the kidney and in the capillary endothelial cells composing the blood-brain barrier and blood-testis barrier. It is also expressed on hematopoietic stem cells, T cells, B cells, and NK cells as well as on many multidrug resistant neoplastic cells.
Additional information: Clone REA495 displays negligible binding to Fc receptors.

Alternative names

ABCB1, ABC20, CLCS, GP170, MDR-1, P-GP, PGY1

Detailed product information

Technical specifications

CloneREA495
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenCD243 (ABCB1)
Alternative names of antigenABCB1, ABC20, CLCS, GP170, MDR-1, P-GP, PGY1
Molecular mass of antigen [kDa]142
Distribution of antigenB cells, endothelial cells, myeloid leukemia cells, NK cells, T cells, stem cells, hematopoietic stem and progenitor cells, bile duct, brain, breast, kidney, liver, small intestine
Entrez Gene ID5243
RRIDAB_2857702, AB_2876929, AB_2876930, AB_2656594, AB_2656595, AB_2656600, AB_2656601, AB_2656604, AB_2656605, AB_2857703

Resources for CD243 (ABCB1) Antibody, anti-human, REAfinity™

Certificates

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References for CD243 (ABCB1) Antibody, anti-human, REAfinity™

Publications

  1. Chen, C. J. et al. (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell 47(7): 381-389
  2. Yao, W. et al. (2014) CD243 gene polymorphism significantly associated with breast cancer susceptibility. Tumour Biol 35(8): 8017-8022
  3. Brambila-Tapia, A. J. (2013) MDR1 (ABCB1) polymorphisms: functional effects and clinical implications. Rev Invest Clin 65(5): 445-454

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