In human blood and bone marrow, CD304 (BDCA-4, Neuropilin-1) is exclusively expressed on plasmacytoid dendritic cells (PDCs), which are characterized as CD11c, CD123bright, and CD303 (BDCA-2)
+
.
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PDCs represent about 0.2% of white blood cells.
They are the main producers of type 1 interferons, which strongly stimulate the differentiation of other immune cells. PDCs have a poor pino- and phagocytosis capacity and take up exogenous antigens predominantly by receptor-mediated endocytosis.
3
Apart from their immune stimulatory functions, they are also intensively discussed to be involved in tolerance induction.
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The CliniMACS® CD304 (BDCA-4)

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