From mid of January on, we offer PepTivator SARS-CoV-2 Select peptide pools, which cover immunodominant epitopes of the whole SARS-CoV-2 proteome. These epitopes originate from structural SARS-CoV-2 proteins (spike protein (S), membrane protein (M), nucleoprotein (N), and envelope protein (E)) as well as non-structural proteins.
The PepTivator SARS-CoV-2 Select peptide pools will be available in two quality grades: MACS GMP, supporting your clinical research, and premium grade, being perfectly suited for your translational and basic research.
MACS GMP PepTivator SARS-CoV-2 Select*:
PepTivator SARS-CoV-2 Select – premium grade:
PepTivator SARS-CoV-2 Select variants:
If you are interested in peptide pools covering the individual structural SARS-CoV-2 proteins, please have a look at our research-grade SARS-CoV-2 PepTivator Peptide Pools.
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), also known as novel coronavirus 2019-nCoV, causes fever, severe respiratory illness, and can lead to life-threatening pneumonia. The first cases of this disease, termed COVID-19 for coronavirus disease 2019, have been detected in December 2019 in Wuhan, China.
The PepTivator SARS-CoV-2 Select pool contains 88 peptides of 9–22 aa in length. 63 of these peptides are MHC class I and 25 peptides are MHC class II–restricted. The peptides originate from structural proteins (S, M, N, E) as well as non-structural proteins.
The peptides are restricted for the following HLA-molecules: HLA-A*01, A*02, A*03, A*11, A*24, A*29, A*30, A*31, A*68, B*07, B*08, B*15, B*27, B*35, B*40, B*44, B*54, B*58, C*07, DRB1*01, DRB1*03, DRB1*04, DRB1*07, DRB1*11, DRB1*15.
The in vitro stimulation of SARS-CoV-2–specific CD4+ and CD8+ T cells with PepTivator SARS-CoV-2 Select causes secretion of effector cytokines and upregulation of activation markers, which then allow the detection and isolation of SARS-CoV-2–specific T cells:
MACS GMP PepTivator SARS-CoV-2 Select:
Premium-grade PepTivator SARS-CoV-2 Select:
MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.
MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. For regulatory status in the USA, please contact your local representative.
Please fill in your contact details if you would like to obtain more information or if you want to pre-order our new SARS-CoV-2 Select PepTivator Peptide Pools.
*MACS GMP Products are for research use and ex vivo cell culture processing only, and are not intended for human in vivo applications. For regulatory status in the USA, please contact your local representative.
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