UltraMicroscope II

Light sheet microscopy for 3D imaging and analysis of entire biological systems

Light sheet fluorescence microscopy with the UltraMicroscope II enables you to visualize whole biological systems. Moving the sample through the light sheets allows the generation of sharp and bright 3D images. Whether imaging large tissue samples or even entire organs, you are equipped for the task at hand regardless of the clearing protocol and imaging solution being used.  
This light sheet microscope comes in two configurations: it can be fitted with either the Zoom Body Module for easy handling in a multi-user environment, or the Super Plan Module that can deliver never-before-seen image resolution and Quality. The Super Plan Module is also available as an upgrade for your UltraMicroscope II.

Benefits

User friendly

An intuitive design, short training time for new users, and minimal staff support requirements make this light sheet microscope the perfect tool for imaging facilities.

Easy adaptation

Apply any clearing protocol and make use of the automated refractive index compensation to maintain high image quality. 

High flexibility

Benefit from our objective lens series designed and optimized specifically for light sheet imaging. Our modular light sheet technology can be tailored to your needs.

From overview to cellular imaging

Explore cellular details in high resolution without losing sight of the big picture.

Features and Specifications

  • Selected references

    1. Culemann, S. et al. (2019) Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature
    2. Sjöstedt, E.. et al. (2020) An atlas of the protein-coding genes in the human, pig, and mouse brain. Science 367(6482)
    3. Kimbrough, A. et al. (2020) Brain-wide functional architecture remodeling by alcohol dependence and abstinence. Proc. Natl. Acad. Sci. U.S.A.
    4. Kirst, C. et al. (2020) Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature. Cell 180(4): 780-795
    5. Schmid, B. et al. (2019) 3Dscript: animating 3D/4D microscopy data using a natural-language-based syntax. Nat. Methods 16(4): 278-280
    6. Todorov, M.I. et al. (2020) Machine learning analysis of whole mouse brain vasculature. Nat. Methods
    7. Ueda, H.R. (2020) Tissue clearing and its applications in neuroscience. Nat. Rev. Neurosci. 21: 61-79
    8. Kullmann, J. et al. (2020) Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit. Neuron
    9. Wan, Y. et al. (2019) Light-Sheet Microscopy and Its Potential for Understanding Developmental Processes Annu. Rev. Cell Dev. Biol. 35: 655-681
    10. Buglak, N. E. (2020) Light Sheet Fluorescence Microscopy as a New Method for Unbiased Three-Dimensional Analysis of Vascular Injury Cardiovasc. Res.
    11. Nie, J. et al. (2019) Fast, 3D Isotropic Imaging of Whole Mouse Brain Using Multiangle‐Resolved Subvoxel SPIM Adv. Sci.
    12. Claser, C. et al. (2019)
      Lung endothelial cell antigen cross-presentation to CD8
      +
      T cells drives malaria-associated lung injury.
      Nat Commun. 10(1): 5066
    13. Levy, R.B et al. (2019) Circuit asymmetries underlie functional lateralization in the mouse auditory cortex. Nat Commun. 10(1): 2783
  • Brochures and posters

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UltraMicroscope II

3D imaging and analysis of entire biological systems

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