MACS® GMP PepTivator® AdV5 Hexon

The MACS GMP PepTivator AdV5 Hexon is a peptide pool that consists mainly of 15-mer peptides with eleven amino-acid overlap. It has been developed for efficient
in vitro
stimulation and subsequent isolation AdV5 hexon-specific CD4
+
and CD8
+
T cells.

Specifications for
MACS
®
GMP PepTivator
®
AdV5 Hexon

Overview

The MACS GMP PepTivator AdV5 Hexon is a peptide pool that consists mainly of 15-mer peptides with eleven amino-acid overlap. It has been developed for efficient
in vitro
stimulation and subsequent isolation AdV5 hexon-specific CD4
+
and CD8
+
T cells.

Detailed product information

Background information

Human adenoviruses (AdV) are ubiquitous lytic DNA viruses, consisting of multiple serotypes and subspecies. AdV infections are associated with significant morbidity and mortality after hematopoetic stem cell transplantations.
The hexon protein is one of the three major proteins of the viral capsid and an immunodominant target antigen for CD4
+
and CD8
+
T cells that is conserved between the serotypes and subspecies.

Applications

Antigen-specific T cells play a critical role in the regulation of immune responses and the elimination of virus-infected or malignant cells in the human body. Adoptive transfer of clinical-grade hexon-specific CD4
+
and CD8
+
T cells is a valuable tool for the treatment of AdV infections after hematopoietic stem cell transplantation (SCT).
1
The
in vitro
stimulation of hexon-specific CD4
+
and CD8
+
T cells with MACS GMP PepTivator AdV5 Hexon causes the production of the effector cytokine IFN-gamma. The secretion of IFN-gamma then permits the enrichment of hexon-specific effector/memory T cells with the use of the CliniMACS Cytokine Capture System (IFN-gamma).
2-4

Quality statement

MACS GMP Products are manufactured and tested under a quality management system (ISO 13485) and are in compliance with relevant GMP guidelines. They are designed following the recommendations of USP <1043> on ancillary materials.

Disclaimer

MACS GMP Products are for
ex vivo
cell processing only, and are not intended for human
in vivo
applications. For regulatory status in the USA, please contact your local representative.

Resources for
MACS
®
GMP PepTivator
®
AdV5 Hexon

Certificates

Please follow this
link
to search for Product Quality Certificates (PQC) by lot number.

References for
MACS
®
GMP PepTivator
®
AdV5 Hexon

Publications

  1. Feuchtinger, T. et al. (2006) Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol 134(1): 64-76
  2. Schultze-Florey, R. E. et al. (2019) Transfer of Hexon- and Penton-selected adenovirus-specific T cells for refractory adenovirus infection after haploidentical stem cell transplantation. Transpl Infect Dis 22(1): doi: 10.1111/tid.13201
  3. Qian, C. et al. (2017) Curative or pre-emptive adenovirus-specific T cell transfer from matched unrelated or third party haploidentical donors after HSCT, including UCB transplantations: a successful phase I/II multicenter clinical trial. J Hematol Oncol. 10(1): 102
  4. Kallay, K. et al. (2018) Early Experience With CliniMACS Prodigy CCS (IFN-gamma) System in Selection of Virus-specific T Cells From Third-party Donors for Pediatric Patients With Severe Viral Infections After Hematopoietic Stem Cell Transplantation. J Immunother 41(3): 158-163

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