REAlease® CD8 Complexes, human

REAlease
®
CD8 Complexes
, human

Clone: REAL100 | Dilution: 1:50
Clone REAL100 is an antibody fragment derived from the full CD8 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL100 recognizes the alpha chain of the human CD8 antigen, a cell-surface glycoprotein also known as Leu-2 or CD8a. CD8 is strongly expressed on human cytotoxic T cells and thymocytes as well as on a subset of NK cells. The CD8 antigen is a disulfide-linked dimer that exists either as a CD8α homodimer or as a CD8α/β heterodimer. CD8 acts as a co-receptor for the T cell receptor and binds to the MHC class I molecules. CD8 is involved in T cell development and activation of mature T cells.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

Leu-2, CD8a, MAL, p32, Cd8b1, LY3, Lyt3, P37, Ly-2

Technical specifications

  • Antigen: CD8
  • Clone: REAL100
  • Isotype control: REAL Control
  • Alternative names of antigen: Leu-2, CD8a, MAL, p32, Cd8b1, LY3, Lyt3, P37, Ly-2
  • Distribution of antigen: T cells, thymocytes, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, VioGreen
  • Selected references

    1. Devine, L. et al. (1999) Orientation of the Ig domains of CD8 alpha beta relative to MHC class I. J. Immunol. 162(2): 846-851
    2. Gao, G. F. et al. (2000) Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor. Immunol. Today 21(12): 630-636
Product options: 6
for 30
tests
(1)
USD 100.00
for 100
tests
(1)
USD 290.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 380.00
for 100
tests
(1)
USD 340.00
for 100
tests
(1)
USD 430.00

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