CDw198 (CCR8) antibodies, mouse

CDw198 (CCR8) antibodies, mouse

Clone: REA921 | Dilution: 1:50
Clone REA921 recognizes the mouse CDw198 antigen, also known as C-C chemokine receptor type 8 (CCR8). CDw198, a G-protein coupled receptor with seven transmembrane regions, is a member of the beta chemokine receptor family, which binds to the T cell activation gene 3 (TCA-3) and CCL1. CDw198 is primarily found in thymus. It is expressed in activated Tʜ2-polarized cells and NK1.1
+
CD4
+
T cells, but also in subsets of monocytes, macrophages, and monocyte-derived dendritic cells. CDw198 plays a role in migration of various cell types into inflammatory sites.
Additional information: Clone REA921 displays negligible binding to Fc receptors.

Alternative names

CCR8, CCR-8, CC-CKR-8

Technical specifications

  • Antigen: CDw198 (CCR8)
  • Clone: REA921
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CCR8, CCR-8, CC-CKR-8
  • Entrez Gene ID: 12776
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: thymocytes, dendritic cells, macrophages, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio615, PE-Vio770, VioBright 515, PE
  • Selected references

    1. Goya, I. et al. (1998) Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. J. Immunol. 160(4): 1975-1981
    2. Zingoni, A. et al. (1998) The chemokine receptor CCR8 is preferentially expressed in Tʜ2 but not Tʜ1 cells. J. Immunol. 161(2): 547-551
    3. Islam, S. A. et al. (2011)
      Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5
      +
      Tʜ2 cells.
      Nat. Immunol. 12(2): 167-177
Product options: 5
30 µg in 200 µL (1)
USD 55.00
30 µg in 200 µL (1)
USD 80.00
30 µg in 200 µL (1)
USD 136.00
30 µg in 200 µL (1)
USD 136.00
30 µg in 200 µL (1)
USD 176.00