CD95 (FAS) antibodies, human

CD95 (FAS) antibodies, human

Clone: REA738 | Dilution: 1:50
Clone REA738 recognizes the human CD95 antigen, also known as Fas and Apo-1, which is a member of the tumor necrosis factor receptor superfamily (TNFR) and is found on the surface of many normal and neoplastically transformed cells. Its ligand, CD95L (FasL/Apo-1L), is able to induce apoptosis in CD95-expressing cells upon binding. CD95 and CD95L are up-regulated on lymphocytes upon activation and are known to play a key role in the regulation of an inflammatory response: Juxtocrine “fratricide” of neighbouring lymphocytes via mutual CD95 and CD95L expression helps to terminate immune responses, while apoptosis of pro-inflammatory cells via CD95 helps maintain immune privilege in sites such as the eye, where CD95L is found to be expressed in the retina and cornea. Cross-linking of CD95 receptors by DX2 monoclonal antibody has been described to induce apoptosis in certain target cells.
Additional information: Clone REA738 displays negligible binding to Fc receptors.

Alternative names

FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6

Technical specifications

  • Antigen: CD95 (FAS)
  • Clone: REA738
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6
  • Entrez Gene ID: 355
  • Molecular mass of antigen [kDa]: 35
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
    ,
    african green monkey (
    Chlorocebus aethiops
    )
    , baboon, capuchin monkey,
    chimpanzee (
    Pan troglodytes
    )
    ,
    common marmoset (
    Callithrix jacchus
    )
    ,
    cotton-top tamarin (
    Saguinus oedipus
    )
    ,
    pigtail monkey (
    Macaca nemestrina
    )
    ,
    sooty mangabey (
    Cercocebus atys
    )
  • Distribution of antigen: lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515, Biotin
  • Selected references

    1. Griffith, T. et al. (1995) Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270: 1189-1192
    2. Lynch, D. et al. (1995) Fas and FasL in the homeostatic regulation of immune responses. Immunol. Today 16: 569-574
    3. Pitcher, C. J. et al. (2002)
      Development and homeostasis of T cell memory in
      rhesus macaque
      .
      J. Immunol. 168: 29-43
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