CD88 (C5AR) antibodies, human

CD88 (C5AR) antibodies, human

Clone: REA1213 | Dilution: 1:50
Clone REA1213 recognizes the human CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 expression is originally described on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on astrocytes, microglia, and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.
Additional information: Clone REA1213 displays negligible binding to Fc receptors.

Alternative names

C5AR1, C5A, C5AR, C5R1

Technical specifications

  • Antigen: CD88 (C5AR)
  • Clone: REA1213
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: C5AR1, C5A, C5AR, C5R1
  • Entrez Gene ID: 728
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: neutrophils, monocytes, macrophages, epithelial cells, endothelial cells, mast cells, astrocytes, microglia, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Gerard, N. P. et al. (1991) The chemotactic receptor for human C5a anaphylatoxin. Nature 349(6310): 614-617
    2. Farzan, M. et al. (2001) Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J. Exp. Med. 193(9): 1059-1066
    3. Buck, E. et al. (2005) Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 102: 2719-2724
Product options: 4
for 30
tests
(1)
USD 102.00
for 100
tests
(1)
USD 278.00
for 30
tests
(1)
USD 122.00
for 100
tests
(1)
USD 288.00