CD87 antibodies, human

CD87 antibodies, human

Clone: VIM5 | Dilution: 1:11
Clone VIM5 recognizes CD87, a 36–38 kDa GPI-anchored cell-surface receptor. CD87, also known uPAR, binds uPA and thus facilitating the catalytic C domain of the uPA to come in close proximity of membrane bound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in-turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. The expression of membrane-bound CD87 is found on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, and keratinocytes. Multiple known regulatory functions of CD87 include cell migration, leukocyte adhesion, chemotaxis, signal transduction, and tissue remodeling.

Alternative names

PLAUR, U-PAR, URKR

Technical specifications

  • Antigen: CD87
  • Clone: VIM5
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: PLAUR, U-PAR, URKR
  • Entrez Gene ID: 5329
  • Molecular mass of antigen [kDa]: 31
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
  • Distribution of antigen: granulocytes, monocytes, dendritic cells, fibroblasts, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770
  • Selected references

    1. May, A. E. et al. (1998)
      Urokinase receptor (CD87) regulates leukocyte recruitment via β2 integrins
      in vivo
      .
      J. Exp. Med. 188: 1029-1037
    2. Tarui, T. et al. (2001) Urokinase-type plasminogen activator receptor (CD87) is a ligand for integrins and mediates cell-cell interaction. J. Biol. Chem. 276: 3983-3990
    3. Ge, Y. et al. (2003) Urokinase plasminogen activator receptor (CD87): something old, something new. Lab. Hematol. 9(2): 67-71
Product options: 10
130-099-472

CD87-FITC, human

for 30
tests
(1)
USD 77.00
130-099-468

CD87-FITC, human

for 100
tests
(1)
USD 232.00
130-099-458

CD87-PE, human

for 30
tests
(1)
USD 97.00
130-099-461

CD87-PE, human

for 100
tests
(1)
USD 272.00
130-099-470

CD87-APC, human

for 30
tests
(1)
USD 124.00
130-099-456

CD87-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 132.00
for 100
tests
(1)
USD 315.00

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