CD86 antibodies, human

CD86 antibodies, human

Clone: REA968 | Dilution: 1:50
Clone REA968 recognizes the human CD86 antigen, also known as B7-2 or B70, which is an 80 kDa molecule and a member of the immunoglobulin superfamily. Together with CD80 (B7-1) it belongs to the B7 family of co-stimulatory molecules. CD86 is expressed on activated B and T cells, dendritic cells, and monocytes/macrophages. The interaction of CD86 with its ligands CD28 and CD152 (CTLA- 4) plays a critical role in induction and regulation of immune responses, e.g., cross-talk between T and B cells, T cell costimulation, or immunoglobulin class-switching. Binding of CD86 to CD28 on T cells results in transduction of costimulatory signals for activation or proliferation of T cells or cytokine production.
Additional information: Clone REA968 displays negligible binding to Fc receptors.

Alternative names

B7-2, B70, CD28LG2, LAB72

Technical specifications

  • Antigen: CD86
  • Clone: REA968
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: B7-2, B70, CD28LG2, LAB72
  • Entrez Gene ID: 942
  • Molecular mass of antigen [kDa]: 35
  • Distribution of antigen: B cells, dendritic cells, Langerhans cells, macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Azuma, M. et al. (1993) B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366(6450): 76-79
    2. Engel, P. et al. (1994) The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen. Blood 84(5): 1402-1407
    3. Lanier, L. L. et al. (1995) CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154(1): 97-105
Product options: 19
130-116-262

CD86-FITC, human

for 30
tests
(1)
USD 81.00
130-116-159

CD86-FITC, human

for 100
tests
(1)
USD 238.00
130-116-263

CD86-PE, human

for 30
tests
(1)
USD 102.00
130-116-160

CD86-PE, human

for 100
tests
(1)
USD 274.00
130-116-264

CD86-APC, human

for 30
tests
(1)
USD 122.00
130-116-161

CD86-APC, human

for 100
tests
(1)
USD 284.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 296.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 296.00
for 30
tests
(1)
USD 144.00
for 100
tests
(1)
USD 310.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 134.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 166.00
for 100
tests
(1)
USD 415.00
for 30
tests
(1)
USD 81.00
for 100
tests
(1)
USD 238.00