CD82 antibodies, human

CD82 antibodies, human

Clone: REA221 | Dilution: 1:11
Clone REA221 recognizes CD82, a member of the four transmembrane domain, tetraspanin family. Tetraspanins contain short, cytoplasmic amino and carboxyl termini and two extracellular loops of unequal sizes and can be distinguished from other membrane proteins, with same topology, due to conserved residues within the transmembrane domains and in the larger extracellular loops. CD82 interacts with other tretaspanins and membrane proteins, thus regulating several functions such as signal transduction. On the surface of tumor cells, CD82 interacts with integrins and is suggested to serve as a supressor of tumor metastasis. In addition, on immune cells such as T cells, CD82 associates with CD81, CD4, or CD8 and class II major histocompatibility complex (MHC), components of the antigen-processing and presentation pathway and tetraspanin CD63, in dendritic cells. Expression of CD82 is found on dendritic cells, monocytes, granulocytes, lymphocytes, epithelial, and endothelial cells.
Additional information: Clone REA221 displays negligible binding to Fc receptors.

Alternative names

4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27

Technical specifications

  • Antigen: CD82
  • Clone: REA221
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27
  • Distribution of antigen: dendritic cells, monocytes, granulocytes, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Lagaudriere-Gesbert, C. et al. (1997) The tetraspanin protein CD82 associates with both free HLA class I heavy chain and heterodimeric beta 2-microglobulin complexes. J. Immunol. 158: 2790-2797
    2. Zhang, X. A. et al. (2003) EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. Cancer Res. 63: 2665-2674
Product options: 10
130-101-309

CD82-FITC, human

for 30
tests
(1)
USD 82.00
130-101-310

CD82-FITC, human

for 100
tests
(1)
USD 232.00
130-101-307

CD82-PE, human

for 30
tests
(1)
USD 97.00
130-101-306

CD82-PE, human

for 100
tests
(1)
USD 272.00
130-101-311

CD82-APC, human

for 30
tests
(1)
USD 124.00
130-101-282

CD82-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 87.00
for 100
tests
(1)
USD 232.00

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