CD79b antibodies, human

CD79b antibodies, human

Clone: REA120 | Dilution: 1:11
Clone REA120 detects the extracellular epitope of CD79b, the β chain of heterodimeric molecule CD79. CD79 is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins (Igs) to form the B cell receptor (BCR). CD79b is 37–39 kDa type I integral membrane protein and like CD79a contains an intracellular immunoreceptor tyrosine-based activation motif (ITAM). CD79a/CD79b heterodimer facilitates differentiation of pre–B cells from pro–B cells, surface expression of sIg, signal transduction following antigen recognition, and enodocytosis of recognised antigens. Patients with chronic lymphocytic leukemia (CLL) B cells lack a functional BCR which is often associated with mutations in CD79b coding region.
Additional information: Clone REA120 displays negligible binding to Fc receptors.

Alternative names

AGM6, B29, Igb

Technical specifications

  • Antigen: CD79b
  • Clone: REA120
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: AGM6, B29, Igb
  • Entrez Gene ID: 974
  • Molecular mass of antigen [kDa]: 23
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J. Immunol. 149: 1548-1555
    2. Koyama, M. et al. (1997) CD79α/CD79β heterodimers are expressed on pro-B cell surfaces without associated μ heavy chain. Int. Immunol. 9: 1767-1772
    3. Gordon, M. S. et al. (2000) Aberrant B cell receptor signaling from B29 (Igβ, CD79b) gene mutations of chronic lymphocytic leukemia B cells. Proc. Natl. Acad. Sci. U.S.A. 97: 5504-5509
Product options: 10
130-099-106

CD79b-PE, human

for 30
tests
(1)
USD 97.00
130-099-104

CD79b-PE, human

for 100
tests
(1)
USD 272.00
130-099-103

CD79b-APC, human

for 30
tests
(1)
USD 124.00
130-099-101

CD79b-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 148.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 132.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 87.00
for 100
tests
(1)
USD 232.00