CD79a antibodies, human

CD79a antibodies, human

Clone: HM47 | Dilution: 1:50
The monoclonal antibody HM47 reacts with the cytoplamic domain of CD79a, which is also known as mb-1 and Ig α. Along with CD79b (Ig β), CD79a is associated with surface Ig (sIg) to form the B cell antigen receptor complex. CD79a is a 47 kDa glycoprotein and comprises a single extracellular immunoglobulin domain, a transmembrane domain, and a signaling intracellular domain with immunoreceptor tyrosine-based activation motif (ITAM). CD79a/CD79b heterodimer facilitates differentiation of pre–B cells from pro–B cells, surface expression of sIg, signal transduction following antigen recognition and enodocytosis of recognised antigens. Surface expression of CD79a dimishes in plasma cells, where it is mainly found as an intracellular molecule. CD79 is considered a B cell–specific marker and is often used to identify the B cell lineage of acute lymphoblastic leukemia. Recent reports however suggest expression of CD79a in T cell acute lymphoblastic leukemia. Individuals lacking CD79a have low/absent circulating pre–B cells and serum antibodies due to a block in B cell development.

Alternative names

Igα, MB-1

Technical specifications

  • Antigen: CD79a
  • Clone: HM47
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: Igα, MB-1
  • Entrez Gene ID: 973
  • Molecular mass of antigen [kDa]: 22
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
    , mouse
  • Distribution of antigen: B cells, lymphocytes, plasma cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J. Immunol. 149: 1548-1555
    2. Mason, D. Y. et al. (1991) The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells. J. Immunol. 147(11): 2474-2482
    3. Minegishi, Y. et al. (1999) Mutations in Igalpha (CD79a) result in a complete block in B-cell development. J. Clin. Invest. 104(8): 1115-1121
    4. Koyama, M. et al. (1997) CD79α/CD79β heterodimers are expressed on pro-B cell surfaces without associated μ heavy chain. Int. Immunol. 9: 1767-1772
    5. Lai, R. et al. (2000) Flow cytometric detection of CD79a expression in T-cell acute lymphoblastic leukemias. Am. J. Clin. Pathol. 113(6): 823-830
Product options: 4
130-124-282

CD79a-PE, human

for 30
tests
(1)
USD 102.00
130-124-235

CD79a-PE, human

for 100
tests
(1)
USD 278.00
130-124-291

CD79a-APC, human

for 30
tests
(1)
USD 122.00
130-124-244

CD79a-APC, human

for 100
tests
(1)
USD 288.00

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