CD7 antibodies, human

CD7 antibodies, human

Clone: REA1244 | Dilution: 1:50
Clone REA1244 recognizes the human CD7 antigen, a single-pass type I membrane protein, also known as leu-9 or GP40. CD7 appears early in T cell ontogeny and is expressed by most T cells in the periphery. It is also found on NK cells, hematopoietic progenitors, monocytes, acute lymphocytic leukemia, and some acute myeloid leukemia cells. Although the ligand is yet not identified, CD7 has been recognized as a costimulatory molecule. CD7 activates phosphatidylinositol 3-kinase which is involved in CD7-mediated regulation of integrin adhesiveness. Furthermore, it has been reported that the β-galactoside-binding lectin galectin-1 binds CD7, leading to induction of apoptosis of thymocytes and T cells, with implications for certain autoimmune diseases and T cell lymphomas.
Additional Information: Clone REA1244 displays negligible binding to Fc receptors.

Alternative names

GP40, Leu-9, TP41, Tp40

Technical specifications

  • Antigen: CD7
  • Clone: REA1244
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: GP40, Leu-9, TP41, Tp40
  • Entrez Gene ID: 924
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: monocytes, NK cells, T cells, tumor cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBlue, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Aruffo, A. et al. (1987) Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. EMBO J. 6(11): 3313-3316
    2. Gallacher, L. et al. (2000)
      Isolation and characterization of human CD34
      Lin
      and CD34
      +
      Lin
      hematopoietic stem cells using cell surface markers AC133 and CD7.
      Blood 95(ARVO Annual Meeting Abstract): 2813-2820
    3. Kobayashi, S. et al. (2013) The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I. PLoS One 8(1): e53728
Product options: 18
130-124-940

CD7-PE, human

for 30
tests
(1)
USD 102.00
130-124-931

CD7-PE, human

for 100
tests
(1)
USD 278.00
130-124-941

CD7-APC, human

for 30
tests
(1)
USD 122.00
130-124-932

CD7-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 126.00
for 100
tests
(1)
USD 310.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 300.00
for 30
tests
(1)
USD 144.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 320.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 320.00
for 30
tests
(1)
USD 135.00
for 100
tests
(1)
USD 385.00
for 30
tests
(1)
USD 83.00
for 100
tests
(1)
USD 241.00