CD68 antibodies, human

CD68 antibodies, human

Clone: Y1/82A | Dilution: 1:10
The monoclonal antibody Y1/82A reacts with CD68, a 110 kDa type I transmembrane glycoprotein classified as a lysosomal/endosomal-associated membrane glycoprotein (LAMP) family member. CD68 is highly expressed by human monocytes and tissue macrophages but also found in subpopulations of B cells, fibroblasts, endothelial, and other cells. It is found predominantely in late endosomal and lysosomal compartments, with a modest level of cell surface expression. CD68 is suggested to be involved in phagocytic activities of tissue macrophages, in intracellular lysosomal metabolism, and extracellular cell-cell and cell-pathogen interactions.

Alternative names

gp110, Lamp4, SCARD1, macrosialin

Technical specifications

  • Antigen: CD68
  • Clone: Y1/82A
  • Isotype: mouse IgG2bκ
  • Isotype control: Mouse IgG2b – isotype control antibodies
  • Alternative names of antigen: gp110, Lamp4, SCARD1, macrosialin
  • Entrez Gene ID: 968
  • Molecular mass of antigen [kDa]: 35
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, basophils, dendritic cells, eosinophils, fibroblasts, Langerhans cells, liver, lymphocytes, macrophages, mast cells, monocytes, myeloid cells, neutrophils, osteoclasts, platelets, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, Biotin
  • Selected references

    1. Saito, N. et al. (1991) Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes. Am. J. Pathol. 139: 1053-1059
    2. Holness, C. L. et al. (1993) Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family. J. Biol. Chem. 268: 9661-9666
    3. Holness, C. L. and Simmons, D. L. (1993) Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood 81: 1607-1613
    4. Kurushima, H. et al. (2000) Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages. J. Leukoc. Biol. 67: 104-108
    5. Gottfried, L. A. et al. (2008) Expression of CD68 in non-myeloid cell types. Scand. J. Immunol. 67: 453-463
Product options: 5
130-100-299

CD68-FITC, human

for 30
tests
(1)
USD 82.00
130-096-964

CD68-FITC, human

for 100
tests
(1)
USD 232.00
130-099-903

CD68-APC, human

for 30
tests
(1)
USD 124.00
130-096-431

CD68-APC, human

for 100
tests
(1)
USD 288.00
for 100
tests
(1)
USD 232.00

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