CD61 antibodies, mouse and rat

CD61 antibodies, mouse and rat

Clone: 2C9.G2 (HMβ3-1) | Dilution: 1:10
Clone 2C9.G2 (HMβ3-1) recognizes a 110 kDa integrin β chain known as CD61 or Integrin β3. Owing to multiple α/β subunit combinations, integrins form an array of heterodimeric receptors, each recognising a multitude of ligands. CD61, in association with either αv (CD51) or αIIb (CD41) integrin, binds to fibrinogen, fibronectin, von Willebrand factor, prothrombin, disintegrins and thrombospondin. Due to binding to various extracellular matrix proteins and cellular receptors, integrins play a significant role in cell adhesion and cell movement. Furthermore, a pro-apoptotic function of CD61 has been suggested using a hepatocellular carcinoma (HCC) cell line and patient tissues. Expression of CD61 is found on platelets, B cell subsets, myeloid cells, mast cells, osteoclasts, endothelium, megakaryocytes, and smooth muscle cells.

Alternative names

ITGB3, GP3A, INGRB3, GPIIIa

Technical specifications

  • Antigen: CD61
  • Clone: 2C9.G2 (HMβ3-1)
  • Isotype: hamster IgGκ
  • Alternative names of antigen: ITGB3, GP3A, INGRB3, GPIIIa
  • Entrez Gene ID: 16416
  • Molecular mass of antigen [kDa]: 84
  • Distribution of antigen: B cells, CNS cells, endothelial cells, fibroblasts, macrophages, mast cells, megakaryocytes, monocytes, platelets, smooth muscle
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Wu, Y. et al. (2009) Proapoptotic function of integrin β3 in human hepatocellular carcinoma cells. Clin. Cancer Res. 15: 60-69
    2. Plow, E. F. et al. (2000) Ligand binding to integrins. J. Biol. Chem. 275: 21785-21788
Product options: 10
9 µg in 300 µL (1)
USD 20.00
30 µg in 1 mL (1)
USD 46.00
9 µg in 300 µL (1)
USD 40.00
30 µg in 1 mL (1)
USD 50.00
9 µg in 300 µL (1)
USD 50.00
30 µg in 1 mL (1)
USD 80.00
9 µg in 300 µL (1)
USD 52.00
30 µg in 1 mL (1)
USD 136.00
9 µg in 300 µL (1)
USD 26.00
30 µg in 1 mL (1)
USD 55.00

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