CD6 antibodies, mouse

CD6 antibodies, mouse

Clone: REA311 | Dilution: 1:10
Clone REA311 recognizes the murine CD6 antigen, a Single-pass type I membrane protein which is expressed on most CD4+CD8+ double-positive, CD4+ or CD8+ single-positive thymocytes, and at highest levels on mature CD3+ thymocytes. In marked contrast to human CD6, mouse CD6 has a long cytoplasmic tail that is not closely related to other proteins. CD6 functions as an adhesion molecule as well as costimulatory molecule for TCR-mediated T cell activation. In thymocytes that express heterogeneous TCR, CD6 increases occur as double-positive thymocytes are selected to a single-positive stage. In contrast, in thymocytes from TCR transgenic mice, CD6 is barely increased following selection, suggesting that as functional avidity increases, requirements for CD6-dependent co-stimulation decrease. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection.
Additional information: Clone REA311 displays negligible binding to Fc receptors.

Alternative names

T-cell differentiation antigen CD6

Technical specifications

  • Antigen: CD6
  • Clone: REA311
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: T-cell differentiation antigen CD6
  • Entrez Gene ID: 12511
  • Molecular mass of antigen [kDa]: 71
  • Distribution of antigen: thymocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Robinson, W. H. et al. (1995) Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA. J. Immunol. 155(10): 4739-4748
    2. Singer, N. G. et al. (2002) CD6: expression during development, apoptosis and selection of human and mouse thymocytes. Int. Immunol. 14(6): 585-597
    3. Whitney, G. et al. (1995) Cloning and characterization of murine CD6. Mol. Immunol. 32(1): 89-92
Product options: 12
130-104-665

CD6-FITC, mouse

9 µg in 300 µL (1)
USD 21.00
130-104-593

CD6-FITC, mouse

30 µg in 1 mL (1)
USD 41.00
130-104-666

CD6-PE, mouse

9 µg in 300 µL (1)
USD 36.00
130-104-594

CD6-PE, mouse

30 µg in 1 mL (1)
USD 56.00
130-104-667

CD6-APC, mouse

9 µg in 300 µL (1)
USD 51.00
130-104-595

CD6-APC, mouse

30 µg in 1 mL (1)
USD 81.00
9 µg in 300 µL (1)
USD 47.00
30 µg in 1 mL (1)
USD 136.00
9 µg in 300 µL (1)
USD 52.00
30 µg in 1 mL (1)
USD 140.00
9 µg in 300 µL (1)
USD 26.00
30 µg in 1 mL (1)
USD 51.00

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