CD56 antibodies, human

CD56 antibodies, human

Clone: REA196 | Dilution: 1:50
Clone REA196 recognizes the human CD56 antigen, a glycoprotein of the Ig-superfamily, also known as neural cell adhesion molecule (NCAM), which is expressed in blood on practically all resting and activated NK cells and on a minor subset of CD3
+
T cells. CD56 is also expressed in brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal-derived tumors, myelomas, and myeloid leukemias also express CD56.
Additional information: Clone REA196 displays negligible binding to Fc receptors.

Alternative names

NCAM1, MSK39, NCAM

Technical specifications

  • Antigen: CD56
  • Clone: REA196
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NCAM1, MSK39, NCAM
  • Entrez Gene ID: 4684
  • Molecular mass of antigen [kDa]: 92
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    )
    ,
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin, VioBright 667
  • Selected references

    1. Camp, B. V. et al. (1990) Plasma cells in multiple myeloma express a natural killer cell- associated antigen: CD56 (NKH-1; Leu-19). Blood 76: 377-382
    2. Vivier, E. et al. (2018) Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells. Cell 175(7): 1731-1743
    3. Boin, F. et al. (2017) Flow cytometric discrimination of seven lineage markers by using two fluorochromes. PLoS One 12(11)
    4. Petty, R. D. et al. (2016) MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: potential diagnostic biomarkers in natural killer (NK) cells of patients with chronic fatigue syndrome (CFS)/ myalgic encephalomyelitis (ME). PLoS One 11: e0150904
    5. Dong, P. et al. (2017) Simultaneous detection of decidual Th1/Th2 and NK1/NK2 immunophenotyping in unknown recurrent miscarriage using 8-color flow cytometry with FSC/Vt extended strategy. Biosci. Rep. 37(3)
    6. Canté-Barrett, K. et al. (2017)
      Loss of CD44
      dim
      expression from early progenitor cells marks T-cell lineage commitment in the human thymus.
      Front Immunol 8: 32
    7. Croci, S. et al. (2018) Higher frequencies of lymphocytes expressing the natural killer group 2D receptor in patients with Behçet disease. Front Immunol 9: 2157
    8. Delso-Vallejo, M. et al. (2017)
      Influence of irradiated peripheral blood mononuclear cells on both
      ex vivo
      proliferation of human natural killer cells and change in cellular property.
      Front Immunol 8
    9. Grant, M. D. et al. (2018) Natural Killer Cells Adapt to Cytomegalovirus Along a Functionally Static Phenotypic Spectrum in Human Immunodeficiency Virus Infection. Front Immunol 9: 2494
    10. Popkin, D. L. et al. (2018)
      In vitro
      evidence that combination therapy with CD16-bearing NK-92 cells and FDA-approved Alefacept can selectively target the latent HIV reservoir in CD4
      +
      CD2
      hi
      memory T cells.
      Front Immunol 9: 2552
    11. Veluchamy, J. et al. (2017)
      In vivo
      efficacy of umbilical cord blood stem cell-derived NK cells in the treatment of metastatic colorectal cancer.
      Front Immunol 8: 87
  • Customer reports and application notes

Product options: 20
130-114-740

CD56-FITC, human

for 30
tests
(1)
USD 81.00
130-114-549

CD56-FITC, human

for 100
tests
(1)
USD 238.00
130-113-874

CD56-PE, human

for 30
tests
(1)
USD 102.00
130-113-312

CD56-PE, human

for 100
tests
(1)
USD 274.00
130-113-872

CD56-APC, human

for 30
tests
(1)
USD 288.00
130-113-310

CD56-APC, human

for 100
tests
(1)
USD 410.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 144.00
for 100
tests
(1)
USD 310.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 325.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 325.00
for 30
tests
(1)
USD 166.00
for 100
tests
(1)
USD 415.00
for 30
tests
(1)
USD 81.00
for 100
tests
(1)
USD 238.00
for 30
tests
(1)
USD 135.00
for 100
tests
(1)
USD 390.00

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