Clone REA196 recognizes the human CD56 antigen, a glycoprotein of the Ig-superfamily, also known as neural cell adhesion molecule (NCAM), which is expressed in blood on practically all resting and activated NK cells and on a minor subset of CD3
T cells. CD56 is also expressed in brain (cerebellum and cortex) and at neuromuscular junctions. Certain large granular lymphocyte (LGL) leukemias, small-cell lung carcinomas, neuronal-derived tumors, myelomas, and myeloid leukemias also express CD56.
Additional information: Clone REA196 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: CD56
  • Clone: REA196
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NCAM1, MSK39, NCAM
  • Entrez Gene ID: 4684
  • Molecular mass of antigen [kDa]: 92
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
    rhesus monkey (
    Macaca mulatta
    cynomolgus monkey (
    Macaca fascicularis
    olive baboon (
    Papio anubis
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio615
  • Selected references

    1. Camp, B. V. et al. (1990) Plasma cells in multiple myeloma express a natural killer cell- associated antigen: CD56 (NKH-1; Leu-19). Blood 76: 377-382
    2. Vivier, E. et al. (2018) Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells. Cell 175(7): 1731-1743
    3. Boin, F. et al. (2017) Flow cytometric discrimination of seven lineage markers by using two fluorochromes. PLoS One 12(11)
    4. Petty, R. D. et al. (2016) MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: potential diagnostic biomarkers in natural killer (NK) cells of patients with chronic fatigue syndrome (CFS)/ myalgic encephalomyelitis (ME). PLoS One 11: e0150904
    5. Dong, P. et al. (2017) Simultaneous detection of decidual Th1/Th2 and NK1/NK2 immunophenotyping in unknown recurrent miscarriage using 8-color flow cytometry with FSC/Vt extended strategy. Biosci. Rep. 37(3)
    6. Canté-Barrett, K. et al. (2017)
      Loss of CD44
      expression from early progenitor cells marks T-cell lineage commitment in the human thymus.
      Front Immunol 8: 32
    7. Croci, S. et al. (2018) Higher frequencies of lymphocytes expressing the natural killer group 2D receptor in patients with Behçet disease. Front Immunol 9: 2157
    8. Delso-Vallejo, M. et al. (2017)
      Influence of irradiated peripheral blood mononuclear cells on both
      ex vivo
      proliferation of human natural killer cells and change in cellular property.
      Front Immunol 8
    9. Grant, M. D. et al. (2018) Natural Killer Cells Adapt to Cytomegalovirus Along a Functionally Static Phenotypic Spectrum in Human Immunodeficiency Virus Infection. Front Immunol 9: 2494
    10. Popkin, D. L. et al. (2018)
      In vitro
      evidence that combination therapy with CD16-bearing NK-92 cells and FDA-approved Alefacept can selectively target the latent HIV reservoir in CD4
      memory T cells.
      Front Immunol 9: 2552
    11. Veluchamy, J. et al. (2017)
      In vivo
      efficacy of umbilical cord blood stem cell-derived NK cells in the treatment of metastatic colorectal cancer.
      Front Immunol 8: 87
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