CD49f antibodies, human and mouse

CD49f antibodies, human and mouse

Clone: REA518 | Dilution: 1:50
Clone REA518 recognizes the human and mouse CD49f antigen, a 120 kDa single-pass type I membrane protein, which is also known as integrin alpha-6 (ITGA6). Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells.
Additional information: Clone REA518 displays negligible binding to Fc receptors.

Alternative names

ITGA6, CD49fB, VLA-6, VLA-6α

Technical specifications

  • Antigen: CD49f
  • Clone: REA518
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGA6, CD49fB, VLA-6, VLA-6α
  • Entrez Gene ID: 3655, 16403
  • Molecular mass of antigen [kDa]: 124, 120
  • Cross-reactivity: porcine, dog,
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    olive baboon (
    Papio anubis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    , capuchin monkey
  • Distribution of antigen: brain, cancer stem cells, epithelial cells, hematopoietic stem cells, kidney, liver, lung, lymphocytes, megakaryocytes, monocytes, ovary, platelets, ES and iPS cells, spleen, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, Biotin, PE-Vio770
  • Selected references

    1. Hynes, R. O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6): 673-687
    2. Aumailley, M. et al. (1990) Antibody to integrin α 6 subunit specifically inhibits cell-binding to laminin fragment 8. Exp. Cell Res. 188(1): 55-60
    3. Hemler, M. E. et al. (1988) Multiple very late antigen (VLA) heterodimers on platelets. Evidence for distinct VLA-2, VLA-5 (fibronectin receptor), and VLA-6 structures. J. Biol. Chem. 263: 7660-7665
    4. Carter, W. G. et al. (1990) Distinct functions for integrins α 3 β 1 in focal adhesions and α 6 β 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J. Cell Biol. 111: 3141-3154
Product options: 6
for 30
tests
(1)
USD 104.00
for 100
tests
(1)
USD 278.00
for 30
tests
(1)
USD 83.00
for 100
tests
(1)
USD 241.00
for 30
tests
(1)
USD 144.00
for 100
tests
(1)
USD 315.00

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