CD49c antibodies, human

CD49c antibodies, human

Clone: REA360 | Dilution: 1:11
Clone REA360 recognizes the human CD49c antigen, a single-pass type I membrane protein also known as integrin α-3 (ITGA3) or VLA-3α. CD49c forms a heterodimer with integrin β1 (α3β1, CD49c/CD29, VLA-3) and plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin. It is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. CD49c/CD29 plays a role in cell-cell and cell-matrix adhesion through binding fibronectin, laminin, collagen, epiligrin, thrombospondin, and CSPG4.
Additional information: Clone REA360 displays negligible binding to Fc receptors.

Alternative names

ITGA3, MSK18, FRP-2, GAP-B3, GAPB3, ILNEB, VCA-2, VL3A, VLA-3α

Technical specifications

  • Antigen: CD49c
  • Clone: REA360
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGA3, MSK18, FRP-2, GAP-B3, GAPB3, ILNEB, VCA-2, VL3A, VLA-3α
  • Entrez Gene ID: 3675
  • Molecular mass of antigen [kDa]: 113
  • Distribution of antigen: epithelial cells, fibroblasts, leukocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Carter, W. G. et al. (1991) Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell 65(4): 599-610
    2. Takada, Y. et al. (1991) Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J. Cell Biol. 115(1): 257-266
    3. de Melker, A. A. et al. (1997) The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. Lab. Invest. 76(4): 547-563
Product options: 14
for 30
tests
(1)
USD 82.00
for 100
tests
(1)
USD 232.00
130-105-407

CD49c-APC, human

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