CD44 antibodies, human

CD44 antibodies, human

Clone: DB105 | Dilution: 1:50
Clone DB105 recognizes the CD44 antigen. CD44 is a marker for many types of cancer stem cells (CSCs), including breast CSCs that possess higher tumorigenicity and metastatic potential, colorectal, pancreatic, and prostate CSCs. In addition, expression was observed in several cancers as well as on carcinoma cell lines. Here, CD44 plays a role in cancer cell migration and matrix adhesion in response to a cellular microenvironment, thus enhancing cellular aggregation and tumor cell growth. CD44 is also expressed on mesodermal cells, such as hematopoietic, fibroblastic, and glial cells.

Alternative names

CSPG9, EMCR III, HCELL, HUTCH-I, CD44s, H-CAM, Pgp-1

Technical specifications

  • Antigen: CD44
  • Clone: DB105
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CSPG9, EMCR III, HCELL, HUTCH-I, CD44s, H-CAM, Pgp-1
  • Entrez Gene ID: 960
  • Molecular mass of antigen [kDa]: 79
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: bone marrow, cancer stem cells, CNS cells, endothelial cells, epithelial cells, kidney, leukocytes, lymphocytes, mesenchymal stem cells, myeloid cells, plasma cells, ES and iPS cells, red blood cells, skeletal muscle, skin, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Al-Hajj, M. et al. (2003) Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100: 3983-3988
    2. Dalerba, P. et al. (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. U.S.A. 104: 10158-10163
    3. Li, C. P. et al. (2007) Identification of pancreatic cancer stem cells. Cancer Res. 67: 1030-1037
    4. Collins, A. T. et al. (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 65: 10946-10951
    5. Aruffo, A. et al. (1990) CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303-1313
    6. Patrawala, L. et al. (2006)
      Highly purified CD44
      +
      prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells.
      Oncogene 25: 1696-1708
    7. Wang, L. et al. (2013) Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy. Int. J. Biol. Sci. 9(5): 472-479
  • Brochures and posters

Product options: 14
130-113-896

CD44-FITC, human

for 30
tests
(1)
USD 81.00
130-113-334

CD44-FITC, human

for 100
tests
(1)
USD 238.00
130-113-897

CD44-PE, human

for 30
tests
(1)
USD 102.00
130-113-335

CD44-PE, human

for 100
tests
(1)
USD 274.00
130-113-893

CD44-APC, human

for 30
tests
(1)
USD 178.00
130-113-331

CD44-APC, human

for 100
tests
(1)
USD 284.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 296.00
for 30
tests
(1)
USD 148.00
for 100
tests
(1)
USD 320.00
for 30
tests
(1)
USD 134.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 82.00
for 100
tests
(1)
USD 242.00

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