CD43 antibodies, human

CD43 antibodies, human

Clone: REA833 | Dilution: 1:50
Clone REA833 recognizes the human CD43 antigen, also known as leukosialin, a cell surface sialoglycoprotein that is involved in cell adhesion, differentiation, and activation. The CD43 antigen is expressed on most leukocytes, i.e., T cells, NK cells, granulocytes, monocytes, and macrophages, on hematopoietic stem cells and on platelets, but not on erythrocytes. Among B cells, CD43 is expressed on activated B cells and plasma cells but not on resting B cells, e.g., naive B cells. In bone marrow, CD43 is found on pro–B cells but is down-regulated during transition to the pre–B cell stage. CD43 is expressed on different myeloid and lymphoid tumors, including some B cell malignancies.
Additional information: Clone REA833 displays negligible binding to Fc receptors.

Alternative names

Spn, Leukosialin, GALGP, gpL115, Lsn, Sialophorin

Technical specifications

  • Antigen: CD43
  • Clone: REA833
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Spn, Leukosialin, GALGP, gpL115, Lsn, Sialophorin
  • Entrez Gene ID: 6693
  • Molecular mass of antigen [kDa]: 38
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: B cells, basophils, bone marrow, granulocytes, lymphocytes, macrophages, megakaryocytes, mesenchymal stem cells, monocytes, neutrophils, NK cells, plasma cells, platelets, red blood cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Whitehead, A. S. et al. (1989) Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Proc. Natl. Acad. Sci. U.S.A. 86(8): 2819-2823
    2. Shelley, C. S. et al. (1990) Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. Biochem. J. 270(3): 569-576
    3. Kudo, S. et al. (1991) A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes. J. Biol. Chem. 266(13): 8483-8489
Product options: 19
130-114-749

CD43-FITC, human

for 30
tests
(1)
USD 84.00
130-114-592

CD43-FITC, human

for 100
tests
(1)
USD 248.00
130-114-750

CD43-PE, human

for 30
tests
(1)
USD 108.00
130-114-593

CD43-PE, human

for 100
tests
(1)
USD 284.00
130-114-751

CD43-APC, human

for 30
tests
(1)
USD 128.00
130-114-594

CD43-APC, human

for 100
tests
(1)
USD 294.00
for 30
tests
(1)
USD 134.00
for 100
tests
(1)
USD 325.00
for 30
tests
(1)
USD 162.00
for 100
tests
(1)
USD 355.00
for 30
tests
(1)
USD 146.00
for 100
tests
(1)
USD 315.00
for 100
tests
(1)
USD 330.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 335.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 335.00
for 30
tests
(1)
USD 84.00
for 100
tests
(1)
USD 248.00

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